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- Since a multi-center MAF is a richer source of data, leading to better science, ideally the ultimate goal should would be for them to supplant single-center MAFs
- As of this writing KICH is among the earliest, if not the firstalong with e.g. COADREAD, to submit a multi-center MAF to the DCC (through BCM)
- THCA is an example where the multi-center mutation calling benchmark results have not yet been merged back into a single MAF for DCC submission
- There is a seemingly implicit understanding that an analyst or programmer from the primary sequencing center has the responsibility of creating the merged multi-center MAF, by incorporating the calls from secondary centers in the benchmark exercise
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